CIRCULATING PROTEIN-Z IN REACTIVE VERSUS PRIMARY THROMBOCYTOSIS AND IN ITP

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概要

• 論文の詳細を見る

• The precise physiological function of protein Z, which is a vitamin K-dependent plasma protein, is still unknown. It is observed that thrombin associates with phospholipid surface in the presence of bovine protein Z. The aim of this study is to determine circulating protein Z in different types of pathological megakaryocytopoiesis. Accordingly, in this cross-sectional study, the plasma concentrations of protein Z in patients with reactive thrombocytosis (RT) and primary thrombocythemia (PT) and in patients with idiopathic thrombocytopenic purpura (ITP) were investigated. We found normal protein Z levels in PT and RT. However, protein Z level was found to be significantly elevated in patients with ITP (p<0.001). The increment of the protein Z concentration seems to be reactive to the increased bleeding tendency of ITP.

• 名古屋市立大学の論文
• 1999-11-30

著者

• Haznedaroglu I

  Hacettepe University Medical School Department Of Internal Medicine

• HAZNEDAROGLU Ibrahim

  Department of Haematology, Hacettepe University Medical School

• OZCEBE Osman

  Department of Haematology, Hacettepe University Medical School

• DUNDAR Semra

  Department of Haematology, Hacettepe University Medical School

• OZATLI Duzgun

  Hacettepe University Medical School, Department of Haematology

• KOSAR Ali

  Hacettepe University Medical School, Department of Haematology

• COBANKARA Veli

  Department of Hematology, Hacettepe University Medical School

• OZATLI Duzgun

  Department of Hematology, Hacettepe University Medical School

• BUYUKASIL Yahya

  Department of Hematology, Hacettepe University Medical School

• KOSAR Ali

  Department of Hematology, Hacettepe University Medical School

• KIRAZLI Serafettin

  Department of Hematology, Hacettepe University Medical School

• Oezcebe O

  Hacettepe University Medical School Department Of Internal Medicine

• Kosar Ali

  Hacettepe University Medical School Department Of Haematology

• Kosar Ali

  Department Of Hematology Faculty Of Medicine Fatih University

• Dundar Semra

  Hacettepe University Medical School Department Of Haematology

• Ozatli Duzgun

  Hacettepe University Medical School Department Of Haematology

• Cobankara Veli

  Hacettepe University School Of Medicine

• Buyukasil Yahya

  Hacettepe University Medical School Department Of Haematology

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