Hyperhomocysteinemia : An Additional Risk Factor in White Coat Hypertension
スポンサーリンク
概要
- 論文の詳細を見る
The association between homocysteine and sustained hypertension (HT) has been studied. The aim of this study was to assess homocysteine levels in white coat hypertension (WCH) as an indicator of increased risk in the development of cardiovascular diseases. WCH was defined as clinical hypertension and a daytime ambulatory blood pressure of < 135/85 mmHg. Plasma levels of homocysteine were determined in patients with WCH, hypertension, and normotension (NT). The study group included 100 subjects, 33 with WCH (16 males, 17 females) aged 49.1 ± 1.9; 35 sustained hypertensives (17 males,18 females) aged 48.5 ± 1.7 and 32 normotensive control subjects (15 males, 17 females) aged 48.8 ± 2.2. The subjects were matched for age, gender, and body mass index. Patients with a smoking habit, dyslipidemia, or diabetes mellitus were not included in the study. Homocysteine levels were analyzed by ELISA. Plasma homocysteine levels were significantly higher in the WCH group compared to the controls (12.32 ± 1.07 versus 5.35 ± 1.38 μmol/L; P < 0.001) and the WCH group had significantly lower homocysteine values than the hypertensives (19.03 ± 0.76 μmol/L P < 0.001). Total cholesterol and tri-glycerides were not different among the groups. There were no statistically significant differences in urinary albumin excretion (UAE) or creatinine clearence between the three groups. Hypertensive retinopathy was observed in the WCH group, but was less severe and less frequent compared to HTs. LVMI was greater in the WCH group compared to the NTs, but significantly less than HTs. The data demonstrate that WCH is associated with high levels of homocysteine. The increase in homocysteine level in WCH is not as high as in SHT. Since an elevated plasma homocysteine level is a strong risk factor for coronary artery disease and there was target organ damage in our WCH group, we conclude that WCH should not be considered to be an innocent trait.
著者
-
Uzun Hafize
Department Of Biochemistry Cerrahpasa Faculty Of Medicine Istanbul University
-
Vehid Suphi
Department Of Public Health Cerrahpasa Faculty Of Medicine Istanbul University
-
Aydin Seval
Department Of Biochemistry Cerrahpasa Faculty Of Medicine Istanbul University
-
Simsek Gonul
Department Of Physiology Cerrahpasa Faculty Of Medicine Istanbul University
-
Karter Yesari
Department Of Internal Medicine Cerrahapasa Medical Faculty Istanbul University
-
Öztürk Esin
Department of Internal Medicine, Taksim Public Hospital
-
Vehid Suphi
Department of Public Health, Taksim Public Hospital
-
Çurgunlu Asll
Department of Internal Medicine, Taksim Public Hospital
-
Ertürk Nurver
Department of Family Medicine, Taksim Public Hospital
-
Kutlu Ayse
Department of Neurology, Taksim Public Hospital
-
Erdine Serap
Cardiology Institute, Cerrahpasa Medical Faculty, Istanbul University
-
Uzun Hafize
Department of Biochemistry, Taksim Public Hospital
関連論文
- The Effects of Nebivolol on Apoptosis in a Rat Infarct Model
- The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats
- Curcumin's Effects on Sialic Acid Level and Sialidase Activity in Ehrlich Ascites Tumor Bearing Mice
- Hyperhomocysteinemia : An Additional Risk Factor in White Coat Hypertension
- N-Acetylcysteine Reduced the Effect of Ethanol on Antioxidant System in Rat Plasma and Brain Tissue
- Effects of Gender on Stress Ulcer Formation in Rats
- The Effect of Hormone Replacement Therapy on Oxidized Low Density Lipoprotein Levels and Paraoxonase Activity in Postmenopausal Women
- Effects of Osteoporotic Cytokines in Ovary-Intact and Ovariectomised Rats with Induced Hyperthyrodism ; Is Skeletal Responsiveness to Thyroid Hormone Altered in Estrogen Deficiency?
- Effect of vitamin C on oxidative liver injury due to isoniazid in rats
- The influence of hemodialysis on serum sialic acid levels in chronic renal failure
- Leukocytoclastic Vasculitis and Renal Cell Carcinoma