Evidence for Anti-Ischemic Effect of Dual-Chamber Pacing in Patients with the Obstructive Form of Hypertrophic Cardiomyopathy
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概要
- 論文の詳細を見る
Dual-chamber pacing reportedly improves the quality of life by reducing the frequency of anginal episodes in selected patients with the obstructive form of hypertrophic cardiomyopathy (HCM), although the underlying mechanism or coronary effect is poorly understood. We report 3 patients with obstructive HCM in whom the effects of atrial vs. dual-chamber tachypacing on systemic hemodynamics and myocardial lactate metabolism were studied. In all patients myocardial lactate production, objective evidence of myocardial ischemia, was demonstrated during atrial pacing, whereas no patient developed myocardial ischemia during dual-chamber pacing. By contrast, the responses of pressure gradient to pacing varied among the patients. These observations demonstrate for the first time that dual-chamber pacing exerted an anti-ischemic effect in obstructive HCM, which may contribute, at least partly, to the beneficial effects of chronic AV pacing on angina status and/or LV function.
- International Heart Journal刊行会の論文
著者
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Mohri Masahiro
Department Of Cardiology Kyushu Kosei-nenkin Hospital
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Ichiki Toshihiro
Department Of Biochemistry Vanderbilt University School Of Medicine
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Takeshita Akira
Department Of Cardiology Faculty Of Medicine Kyushu University
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Kuga Takeshi
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
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