Effects of the Angiotensin-converting Enzyme Inhibitor Enalapril on Sympathetic Neuronal Function and .BETA.-adrenergic Desensitization in Heart Failure after Myocardial Infarction in Rats.
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概要
- 論文の詳細を見る
One of the beneficial effects of angiotensin-converting enzyme (ACE) inhibitors in the treatment of heart failure may derive from sympathoinhibition and the prevention of β-adrenergic desensitization. However, the roles of these properties in the overall effects of ACE inhibitor are not clear. We studied the effects of chronic enalapril treatment (20 mg/L in drinking water for 12 weeks) on left ventricular (LV) function, cardiac norepinephrine (NE), sympathetic neuronal function assessed by 131I-metaiodobenzylguanidine (MIBG), β-receptors, and isometric contraction of papillary muscle in rats with myocardial infarction (MI) induced by coronary artery ligation. Decreased LV function in the MI rats was associated with reduced cardiac NE content and MIBG uptake, and severely blunted responses of non-infarcted papillary muscle to isoproterenol, forskolin, and calcium. Enalapril attenuated LV remodeling in association with a reduction of the ventricular loading condition and restored baseline developed tension of non-infarcted papillary muscle to the level of sham-operated rats. However, enalapril did not improve cardiac NE content, MIBG uptake, or inotropic responsiveness to β-agonists. These results suggest that the major effect of the ACE inhibitor enalapril in the treatment of heart failure is not due to sympathoinhibition or restoration of β-adrenergic pathway in this model of heart failure.
- International Heart Journal刊行会の論文
著者
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Inoue Hiroshi
2nd Department of Internal Medicine, University of Toyama
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Nozawa Takashi
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Asanoi Hidetsugu
2nd department of internal medicine, Toyama Medical and Pharmaceutical University
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Igawa Akihiko
2nd Department of Internal Medicine, Toyama Medical and Pharmaceutical University
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Inoue Minoru
Research Laboratories Daiichi Radioisotope Laboratories
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Yamada Yoshihisa
First Inst. Of New Drug Discovery Otsuka Pharmaceutical Co. Ltd.
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Fujii Nozomu
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Inoue Minoru
Research Laboratories, Daiichi Radioisotope Lab., Ltd.
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Yamada Yoshihisa
First Institute of New Drug Research, Otsuka Pharmaceutical Co, Ltd
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Yoshida Naohiro
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Kato Bun-ichi
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Tazawa Shusaku
Research Laboratories, Daiichi Radioisotope Lab., Ltd.
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Asanoi Hidetsugu
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Inoue Hiroshi
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Nozawa Takashi
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Igawa Akihiko
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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Kato Bun-ichi
2nd Department of Internal Medicine, Toyama Medical & Pharmaceutical University
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