肝マイクロ波凝固によるheat shock protein 70の発現

概要

論文の詳細を見る
Purpose : Microwave coagulation therapy (MCT) has been performed as treatment of non-resectable hepatocellular carcinoma. We assessed the expression of heat shock protein (HSP) 70 having anti-tumor effects on hepatic MCT.Methods : The livers of adult white rabbits were irradiated using microwave tissue coagulator. The specimens were extracted at a distance 1.5 (point A) and 3.0 cm (point B) from the center of the coagulated tissue : before, 10, 30, 60, 90, and 120 minutes after irradiation. The detection of HSP70 was performed using indirect immunofluorescence analysis.Results : The expression of HSP70 was detected point A found from 10 minutes after irradiation. The expression of HSP70, however, was not detected at point B during observation period.Conclusion : The expression of HSP70 in hepatic microwave tissue coagulation possibly contributed to enhancement of anti-tumor effect.
特定非営利活動法人 Microwave Surgery研究会の論文