サルモネラおよび枯草菌の自然突然変異に対するL-エチオニンの抗変異効果〔英文〕

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概要

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• L-ethionine, a hepatocarcinogen, exhibited a strong bio-antimutagenic effect against spontaneous mutation in Ames Salmonella strains as well as in a Bacillus subtilis mutator strain whose mutator activity was due to an error-prone DNA replicating enzyme. The bio-antimutagenic effect of L-ethionine was completely abolished by the presence of L-methionine, but not by D-methionine, suggesting that genetic effect of L-ethionine was expressed through its interaction with L-methionine metabolism in the treated cells.

著者

• 井上 正

  Laboratory of Nucleic Acid Science, College of Bioresource Sciences, Nihon University

• INOUE Tadashi

  Laboratory of Nucleic Acid Science, Department of Applied Bilogical Science, College of Bioresource

• SUZUKI Otoya

  Laboratory of Mutagenesis, National Institute of Genetics

• KADA Tsuneo

  Laboratory of Mutagenesis, National Institute of Genetics

• FUJII Taro

  Genetic Stock Research Center, National Institute of Genetics

• 鈴木 音哉

  Laboratory of Mutagenesis, National Institute of Genetics

• 賀田 恒夫

  Laboratory of Mutagenesis, National Institute of Genetics

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• サルモネラおよび枯草菌の自然突然変異に対するL-エチオニンの抗変異効果〔英文〕

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