単離微小核を用いた色素性乾皮症細胞へのヒトDNA修復遺伝子の導入〔英文〕
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概要
- 論文の詳細を見る
Microcells were prepared by enucleation of micronucleated normal human diploid cells and these microcells were purified by using bovine serum albumin gradient. SV40-transformed xeroderma pigmentosum (XP) cells were fused with the purified microcells and UV resistant clones were obtained. Analysis of UV sensitivity and chromosome numbers of the transferred clones indicated that a part of genome of normal human cells were transferred and the gene(s) controlling excision repair of UV damage should have been introduced into the XP cells. Identification of chromosome(s) responsible for the DNA repair was not possible because of aberrent chromosome constitution of the recipient cells.
- 日本遺伝学会の論文
著者
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Ishizaki Kanji
Radiat. Biol. Center Ryoto Univ.
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Shima Akihiro
Department Of Biological Sciences Graduate School Of Science University Of Tokyo.
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TAKEBE HIRAKU
Radiation Biology Center, Kyoto University
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SEKIGUCHI Toyozo
Division of Radiobiology, National Cancer Center Research Institute
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Shima Akihiro
Department Of Biological Sciences Graduate School Of Science University Of Tokyo
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SHIMA Akihiro
Department of Experimental Radiology, Shiga University of Medical Science
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石崎 寛治
Radiation Biology Center, Kyoto University
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- 単離微小核を用いた色素性乾皮症細胞へのヒトDNA修復遺伝子の導入〔英文〕
- Sensitivity to mutagens of cell lines with high expression of fish CPD photolyase c-DNA
- Human chromosome transfer to XP-C cells by microcell fusion