ショウジョウバエBarの眼原基の発生過程における微細構造と細胞化学的研究〔英文〕

概要

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Attempts were made to study the relative frequency of the degenerating cells in the Bar eye discs at different developmental stages of Drosophila melanogaster. The cells of the degenerative area in the eye discs contain several dense inclusion bodies of varied internal structure. These are myelin like figure, cell organelles fragment and lipid droplet and which are found in the eye disc cells. The frequency of these types of fragments changes in different stages of the eye disc. Most of these electron dense bodies which were limited by a single membrane showed acid phosphatase reaction products. This acid phosphatase-positive and membrane-bounded structure may be defined as lysosomes. These fine structural changes and their association with acid phosphatase reaction products are interpreted as changes in lysosomes going from prelysosomes to lysosomes and finally to post types. The lysosomes in the Bar eye discs decrease considerably resulting from the acetamide-treatment. These results further suggest that acetamide acts to inhibit the formation of lysosomes during cytodifferentiation of the cell clusters in the Bar eye discs
日本遺伝学会の論文