Novel Functional Nano-size Nonionic Surfactant Particles on Which Cationic Metalloporphyrins Are Absorbed; Preparation, Characterization, and Anti-oxidant Properties

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概要

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• Cationic manganese (III) 5,10,15,20-tetrakis (N-methylpyridinium-2-yl) porphyrin (MnT2MPyP) and manganese (III) 5,10,15,20-tetrakis (N-methylpyridinium-4-yl) porphyrin (MnT4MPyP) complexes were synthesized as superoxide dismutase (SOD) mimics which were introduced into niosomes so as to examine this effects on the capacity of drug delivery system (DDS) to maintain and perpetuate blood circulation. All the niosomes were prepared from polyoxyethylene solbitan monostearate (Tween 61) by the conventional sonication method. SOD activity was measured by the stopped-flow analysis and the cytochrome c method. Sodium stearate-linked MnT2MPyP was found to be the most effective catalyst along with SOD activity for decomposing O2-· at a second-order rate constant of 2.0×107 M-1s-1 in Tween 61 niosomes. Rate constants of metalloporphyrin-embedded niosomes for reaction with hydrogen peroxide (H2O2) and half-life times in H2O2 were also determined. Metalloporphyrin-embedded niosomes were found to have greater half-life times compared to metalloporphyrin without niosomes. The present findings clearly indicate that metalloporphyrin-embedded niosomes are highly effective for bringing about O2-· decomposition and should thus find application as DDS in antioxidant drugs.

• 日本油化学会の論文

著者

• Oyaizu Kenichi

  Institute of Colloid and Interface Science, Tokyo University of Science

• Yuasa Makoto

  Department Of Polymer Chemistry Waseda University

• Yamaguchi Aritomo

  Department Of Chemistry Graduate School Of Science The University Of Tokyo

• Hanyuu Yukihiro

  Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science

• KASAHARA Kazunori

  Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science

• YUASA Makoto

  Department of Industrial Chemistry, Faculty of Science and Technology, Science University of Tokyo

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