Synthesis of Hexameric Manganese Porphyrin as an SOD Mimic and SOD Activity〔邦文〕

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概要

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• Free radicals and related species derived from O2 such as superoxide anion radical (O2-·), hydrogen peroxide (H2O2), hydroxyl radical (·OH) and peroxynitrite ion (ONOO-) are often generated in organisms with possibly consequent diseases. The enzyme, superoxide dismutase (SOD), catalyzes the reaction which eliminates O2-· As models of SOD, manganese porphyrins such as [meso-tetrakis(N-methylpyridinium-4-yl)porphyrinato] manganese(III) (MnT4MPyP) have been investigated. However, the half-life of any one of these in the blood is usually quite short. We undertook the design of a novel hexameric manganese porphyrin (HexMnP) capable of remaining for a prolonged period in the blood. The SOD activity of HexMnP (IC50 = 2.1 ± 0.7 μM) was found to be somewhat less than that of MnT4MPyP (IC50 = 0.71 μM), but to exceed that of reconstituted hemoglobin (MnT4MPyP-Hb) (IC50 = 2.0 μM) prepared in a previous study. HexMnP proved to be an effective SOD model in which HexMnP had the capacity to remain over a long period of time in the blood, owing to its molecular diameter of more than 80Å.

• 日本油化学会の論文

著者

• Oyaizu Kenichi

  Institute of Colloid and Interface Science, Tokyo University of Science

• Yamaguchi Aritomo

  Department Of Chemistry Graduate School Of Science The University Of Tokyo

• Hayashi Takamitsu

  Department Of Life Science Aichi University Of Education

• Hanyuu Yukihiro

  Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science

• YUASA Makoto

  Department of Industrial Chemistry, Faculty of Science and Technology, Science University of Tokyo

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• Synthesis of Hexameric Manganese Porphyrin as an SOD Mimic and SOD Activity〔邦文〕
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