Changes in Rat Uterine and Cervical phospholipase A2 Activity Following Progesterone Agonist or Antagonist Administration at Term

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Our previous study revealed that a fall in plasma progesterone (P4) level was associated with a transient increase in cytosolic phospholipase A2 (PLA2) activity and prostaglandin F2α level in the rat uterus and cervix during natural parturition. This study determined the changes in the PLA2 activities during modulated occurrence of delivery by P4 antagonist or agonist late in pregnancy. In rats undergoing P4 antagonist-induced preterm delivery, the PLA2 activities of both uterine and cervical cytosol significantly decreased 12 hours after the challenge and tended to be attenuated within 72 hours. The plasma P4 level altered in a similar pattern. Blockade of delivery by chronic treatment with P4 agonist was not associated with changes in uterine PLA2 activity compared with that in normally delivering rats, although there was a persistent rise in cervical PLA2 activity. The obtained data indicates that the PLA2 activities in rat uterine and cervical cytosol are not regulated solely by P4 and that delivery can occur without activation of this enzyme.
日本繁殖生物学会の論文