Gestational Exposure to Nonylphenol Causes Precocious Mammary Gland Development in Female Rat Offspring

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概要

• 論文の詳細を見る

• This study examined whether or not exposure to 4-nonylphenol (NP) during late gestation affects reproductive and mammary development in the offspring of female rats. Time pregnant Long Evans rats were gavaged with NP (10 or 100 mg/kg), atrazine (ATR, 100 mg/kg), or corn oil on gestation days 15-19. The uterus weights of the NP (100 mg/kg/d)-exposed pups were higher than those of the controls but the weights of the other organs were unchanged. Delayed mammary gland (MG) development was detected in the ATR pups on PND 4 and persisted through to PND 66. The high dose NP pups had advanced lobular development of their MG on PND 22, while the glands from the low dose NP pups were no different morphologically from the controls. Immunohistochemical comparisons of the mammary sections from PND 41 demonstrated low levels of estrogen receptor (ER) staining in the control gland stroma and epithelium but higher levels in the tissue of the pups exposed to NP and ATR. ATR also elevated ER in the stroma surrounding the epithelial layer of the terminal end buds. The level of progesterone receptor (PR) staining was markedly lower in the epithelium of the 100 mg/kg NP glands vs. the control glands. However, PR was present at high levels in the epithelium of the 10 mg/kg NP glands and was even more prominent in the ATR-exposed ductal epithelium and fat cell nuclei. The level of prolactin staining was only elevated in glands containing lobule areas (NP-exposed) compared with the control levels. These results suggest that NP and ATR have opposite effects on the development of MG after gestational exposure. Exposure to them during the critical period of epithelial outgrowth altered the receptor levels of mammary progesterone and prolactin and might contribute to the differences in the mammary morphology at PND 41.

• 日本繁殖生物学会の論文

著者

• KIM Tae

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Adminis

• KANG Il

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Adminis

• MOON Hyun

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Adminis

• Moon Hyun

  Endocrine Toxicology Team National Institute Of Toxicological Research Korea Food And Drug Administr

• Choi Jae

  College Of Pharmacy Pusan National University

• Shin Jae-ho

  Department Of Biomedical Laboratory Science College Of Health Science Eulji University

• Shin Jae-Ho

  Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Adm

• Moom Hyun

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Adminis

• Han Soon

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Adminis

• HONG Jin

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Adminis

• KIM Seung-Hee

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Adminis

• FENTON Suzanne

  Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S

• Fenton Suzanne

  Reproductive Toxicology Division National Health And Environmental Effects Research Laboratory U.s.

• Hong Jin

  Endocrine Toxicology Team National Institute Of Toxicological Research Korea Food And Drug Administr

• Kim Tae

  Endocrine Toxicology Team National Institute Of Toxicological Research Korea Food And Drug Administr

• KANG IL

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration

• KANG Il

  Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration

• KIM Tae

  Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration

• KIM Seung-Hee

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration

• HAN Soon

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration

• SHIN Jae-Ho

  Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration

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