Identifying 6,7,4'-Trihydroxyisoflavone as a Potent Tyrosinase Inhibitor
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概要
- 論文の詳細を見る
A known biotransformed compound, 6,7,4′-trihydroxyisoflavone, was identified as a potent tyrosinase inhibitor. It inhibited mushroom tyrosinase with an IC50 value of 9.2 μM, which is six times the anti-tyrosinase activity of kojic acid (IC50=54.4 μM). The inhibition kinetics, analyzed by Lineweaver–Burk plots, indicated 6,7,4′-trihydroxyisoflavone to be a competitive inhibitor of tyrosinase when L-tyrosine was used as a substrate. Its biosynthesis precursors and analogs, including glycitein, daidzein, and genistein, showed little anti-tyrosinase activity. The results suggest that hydroxyl groups at the C-6 and C-7 positions of the isoflavone skeleton might play an important role in the expression of tyrosinase inhibitory activity.
- 社団法人 日本農芸化学会の論文
- 2005-10-23
著者
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Chang Te-Sheng
Department of Biological Science and Technology, National University of Tainan
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Ding Hsiou-Yu
Department of Cosmetics Science, Chia Nan University of Pharmacy and Science
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LIN Hang-Ching
School of Pharmacy, National Defense Medical Center
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Ding Hsiou-yu
Dep. Of Cosmetics Sci. Chia Nan Univ. Of Pharmacy And Sci.
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Lin Hang-ching
School Of Pharmacy National Defense Medical Center
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Chang Te-sheng
Dep. Of Biological Sci. And Technol. National Univ. Of Tainan
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Ding Hsiou-yu
Department Of Cosmetics Science Chia Nan University Of Pharmacy And Science
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Chang Te-sheng
Department Of Biological Science And Technology National University Of Tainan
関連論文
- Metabolism of the Soy Isoflavones Daidzein and Genistein by Fungi Used in the Preparation of Various Fermented Soybean Foods
- Glycosides from Paeonia suffruticosa
- Identifying 6,7,4'-Trihydroxyisoflavone as a Potent Tyrosinase Inhibitor
- Metabolism of the Soy Isoflavones Daidzein and Genistein by Fungi Used in the Preparation of Various Fermented Soybean Foods
- In Vitro and Vivo Melanogenesis Inhibition by Biochanin A from Trifolium pratense