In Vitro and Vivo Melanogenesis Inhibition by Biochanin A from Trifolium pratense

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概要

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• Our previous study showed that a methanol extract from Trifolium pratense exerted potent inhibitory activity on melanogenesis in mouse B16 melanoma cells. In the present study, the active compound in this Chinese herb extract was isolated and identified as biochanin A by mass spectrum, 1H-NMR, and 13C-NMR analysis. The inhibitory effects of biochanin A on melanogenesis were investigated in vitro in cultured melanoma cells and in vivo in zebrafish and mice. Biochanin A dose-dependently inhibited both melanogenesis and cellular tyrosinase activity in B16 cells and in zebrafish embryos. Application of a cream containing 2% biochanin A twice daily to the skin of mice also increased the skin-whitening index value after 1 week of treatment, and the increase continued for another 2 weeks. Biochanin A was confirmed as a good candidate for use as a skin-whitening agent in the treatment of skin hyperpigmentation disorders.

• 2011-05-23

著者

• Ding Hsiou-yu

  Institute Of Cosmetic Science Chia Nan University Of Pharmacy And Science

• Chang Te-sheng

  Department Of Biological Science And Technology National University Of Tainan

• Ding Hsiou-yu

  Institute Of Cosmetics Science Chia Nan University Of Pharmacy And Science

• Tsai Pin-chin

  Department Of Pharmacy E-da Hospital

• LIN Victor

  Department of Urology, E-Da Hospital

• WU Jiumn-Yih

  The PhD Program in Biotechnology, Institute of Biotechnology and Chemical Engineering, I-Shou Univer

• LU Yen-Hsing

  Department of Biological Science and Technology, National University of Tainan

• Lin Victor

  Department Of Urology E-da Hospital

• Lu Yen-hsing

  Department Of Biological Science And Technology National University Of Tainan

• Wu Jiumn-yih

  The Phd Program In Biotechnology Institute Of Biotechnology And Chemical Engineering I-shou Universi

関連論文

• Identifying 6,7,4'-Trihydroxyisoflavone as a Potent Tyrosinase Inhibitor
• Inhibition of melanogensis by a novel origanoside from Origanum vulgare
• Metabolism of the Soy Isoflavones Daidzein and Genistein by Fungi Used in the Preparation of Various Fermented Soybean Foods
• In Vitro and Vivo Melanogenesis Inhibition by Biochanin A from Trifolium pratense
• trans-Caffeic Acid Stearyl Ester from Paeonia suffruticosa Inhibits Melanin Synthesis by cAMP-Mediating Down-Regulation of α-Melanocyte-Stimulating Hormone-Stimulated Melanogenesis Signaling Pathway in B16 Cells

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