Enantioselective Total Synthesis of Enokipodins A-D, Antimicrobial Sesquiterpenes Produced by the Mushroom, Flammulina velutipes
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概要
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The first enantioselective total synthesis of enokipodins A, B, C and D, highly oxidized α-cuparenone-type sesquiterpenoids possessing antimicrobial activity, was accomplished in 8–28% overall yields from methyl (2,5-dimethoxy-4-methylphenyl)acetate by applying Meyers’ diastereoselective alkylation protocol for the construction of their C7-quaternary asymmetric center. The present synthesis confirmed the absolute configuration of the enokipodins, and also constitutes a formal enantioselective synthesis of (S)-1,4-cuparenediol and (S)-cuparene-1,4-quinone.
- 2005-02-23
著者
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Kuwahara Shigefumi
Laboratory Of Agricultural Chemicals Faculty Of Agriculture Ibaraki University
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Kuwahara Shigefumi
Laboratory Of Applied Bioorganic Chemistry Graduate School Of Agricultural Science Tohoku University
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SAITO Mana
Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku Universi
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Saito M
Laboratory Of Applied Bioorganic Chemistry Graduate School Of Agricultural Science Tohoku University
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