Myricitrin Degraded by Simulated Digestion Inhibits Oxidation of Human Low-Density Lipoprotein

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概要

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• The inhibitory effects of myricitrin on the oxidation of human low-density lipoprotein were investigated before and after its degradation by simulated digestion. Myricitrin strongly inhibited the low-density lipoprotein oxidation induced by either 2,2′-azobis (2-amidinopropane) dihydrochloride or CuSO4 in a concentration-dependent manner. Myricitrin was very stable under an acidic condition (pH 1.8) corresponding to the gastric environment, but it was easily degraded under an alkaline condition (pH 8.5) corresponding to the intestinal environment. However, degraded myricitrin also had a strong inhibitory effect on the oxidative degradation of α-tocopherol, cholesterol and apolipoprotein B-100 in low-density lipoprotein. Our study revealed that myricitrin was degraded into many components under a mildly alkaline condition, but the degraded myricitrin still retained the free radical-scavenging and copper-chelating activities toward low-density lipoprotein.

• 社団法人 日本農芸化学会の論文
• 2005-04-23

著者

• MORIWAKI Masamitsu

  Fundamental Research Division, San-Ei Gen F.F.I. Corporation

• Yokomizo Atsushi

  Fundamental Research Division San-ei Gen F. F. I. Corporation

• Moriwaki Masamitsu

  Fundamental Research Division San-ei Gen F. F. I. Corporation

関連論文

• Enzymatic Production of Highly Soluble Myricitrin Glycosides Using β-Galactosidase
• Effect of Enzymatically Modified Isoquercitrin in Spontaneously Hypertensive Rats
• Myricitrin Degraded by Simulated Digestion Inhibits Oxidation of Human Low-Density Lipoprotein
• Effects of Uptake of Flavonoids on Oxidative Stress Induced by Hydrogen Peroxide in Human Intestinal Caco-2 Cells
• Transepithelial Permeability of Myricitrin and Its Degradation by Simulated Digestion in Human Intestinal Caco-2 Cell Monolayer

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