Kinetics of the Ceramide Kinase Inhibitor K1, a Suppressor of Mast-Cell Activation
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概要
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In a previous study, we synthesized a novel inhibitor of ceramide kinase, K1. In this study, we determined that inhibition by K1 is non-competitive and that four intact six-membered rings are important to the inhibitory activity. Furthermore, we identified an effective in vivo concentration for K1, at which it did not influence any cellular lipid synthesis other than that of ceramide 1-phosphate (C1P) using RBL-2H3 cells, and found that K1 suppressed the activation of mast cells.
- 社団法人 日本農芸化学会の論文
著者
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IGARASHI Yasuyuki
Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido
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MITSUTAKE Susumu
Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Sciences and Facult
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Kumada Hirotaka
Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Science and Faculty
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Inagaki Yuichi
Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Science and Faculty
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MITSUNAGA Shino
School of Science and Technology, Kwansei Gakuin University
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TSUCHIKAWA Hiroshi
School of Science and Technology, Kwansei Gakuin University
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KATSUMURA Shigeo
School of Science and Technology, Kwansei Gakuin University
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