Indole-3-carbinol Suppresses Tumor-Induced Angiogenesis by Inhibiting Tube Formation and Inducing Apoptosis

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概要

• 論文の詳細を見る

• Indole-3-carbinol (I3C) has been reported to exert anticancer activity in vivo. However, its anticancer mechanism has not been fully elucidated. In this study, we demonstrate that I3C suppressed tumor-induced angiogenesis and tube formation of endothelial cells. I3C also induced apoptosis in endothelial cells by activating the caspase cascade. We propose that I3C exerts its anticancer effect through the induction of endothelial apoptosis.

• 社団法人 日本農芸化学会の論文

著者

• Kunimasa Kazuhiro

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• Kobayashi Tomomi

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• Sugiyama Sayuri

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• KAJI Kazuhiko

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• OHTA Toshiro

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

関連論文

• Indole-3-carbinol Suppresses Tumor-Induced Angiogenesis by Inhibiting Tube Formation and Inducing Apoptosis
• Propolis Suppresses Tumor Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells
• Propolis Suppresses Tumor Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells
• Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo
• Indole-3-carbinol Suppresses Tumor-Induced Angiogenesis by Inhibiting Tube Formation and Inducing Apoptosis

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