Inhibition of Thioredoxin Reductase by Curcumin Analogs

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概要

• 論文の詳細を見る

• Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR). Most of them were more potent TrxR inhibitors than natural curcumin. The structure-activity relationship was summarized, and the curcumin analog was found to inhibit TrxR irreversibly in a time-dependent manner. The action was caused by covalent modification of the redox-active residues Cys497 and Sec498 in TrxR.

• 社団法人 日本農芸化学会の論文

著者

• Liu Zhong

  School Of Chinese Medicine Hong Kong Baptist University

• GU Lian-Quan

  School of Chemistry and Chemical Engineering, Sun Yat-Sen University

• HUANG Zhi-Shu

  School of Chemistry and Chemical Engineering, Sun Yat-Sen University

• DU Zhi-Yun

  School of Pharmaceutical Sciences, Sun Yat-sen University

• LEE Kin-Sing

  Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University

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