Inhibition of Thioredoxin Reductase by Curcumin Analogs
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概要
- 論文の詳細を見る
Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR). Most of them were more potent TrxR inhibitors than natural curcumin. The structure-activity relationship was summarized, and the curcumin analog was found to inhibit TrxR irreversibly in a time-dependent manner. The action was caused by covalent modification of the redox-active residues Cys497 and Sec498 in TrxR.
- 社団法人 日本農芸化学会の論文
- 2008-08-23
著者
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Liu Zhong
School Of Chinese Medicine Hong Kong Baptist University
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Liu Zhong
School Of Chinese Medicine Hong Kong Baptist Univ.
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GU Lian-Quan
School of Chemistry and Chemical Engineering, Sun Yat-Sen University
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HUANG Zhi-Shu
School of Chemistry and Chemical Engineering, Sun Yat-Sen University
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Huang Zhi-shu
School Of Chemistry And Chemical Engineering Sun Yat-sen University
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Gu Lian-quan
School Of Chemistry And Chemical Engineering Sun Yat-sen University
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DU Zhi-Yun
School of Pharmaceutical Sciences, Sun Yat-sen University
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LEE Kin-Sing
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University
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Gu Lian-quan
School Of Pharmaceutical Sciences Sun Yat-sen University
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Huang Zhi-shu
School Of Pharmaceutical Sciences Sun Yat-sen University
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Liu Zhong
School Of Pharmaceutical Sciences Sun Yat-sen University
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Du Zhi-yun
School Of Pharmaceutical Sciences Sun Yat-sen University
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Lee Kin-sing
Department Of Applied Biology And Chemical Technology The Hong Kong Polytechnic University
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