Synthesis and structure-activity relationship of N-(acyl)muramoyl-dipeptides.

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概要

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• A variety of N-(acyl)muramoyl-dipeptides were synthesized and their immunoadjuvant activities were examined on the induction of delayed-type hypersensitivity to N-acetyl-L-tyrosine-3-azobenzene-4'-arsonate in guinea pigs. It was found that introduction of acyl groups to the 2-amino group in muramoyl-L-valyl- or -L-seryl-D-isoglutamine reduced the activity with the increasing length of the acyl group, although all N-(acyl)muramoyl-L-alanyl-D-isoglutamines were active as an adjuvant. The results suggest that development of the adjuvant activity of N-(acyl)muramoyldipeptides is closely related to both the length of the acyl group and the bulkiness of the peptide moiety.

• 公益社団法人 日本農芸化学会の論文

著者

• OKUMURA Hiroyuki

  Institute of Immunological Science, Hokkaido University

関連論文

• Synthesis and Immunoadjuvant Activity of Acylamino Analogs of N-Acetylmuramoyl-L-alanyl-D-isoglutamine
• Biological Activities of Fundamental, Carbohydrate Skeleton of Lipid A Containing Amide-linked 3-Hydroxytetradecanoic Acid
• Synthesis and structure-activity relationship of N-(acyl)muramoyl-dipeptides.

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