Moranoline (1-deoxynojirimycin) fermentation and its improvement.

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概要

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• Moranoline (1-deoxynojirimycin) is a strong α-glucosidase inhibitor. A rapid screening method for isolation of moranoline-producing Streptomyces (oblate agar plate method) was developed. A glucoamylase inhibitor was isolated from the culture filtrate of Streptomyces lavendulae GC-148, a mutant strain obtained from Streptomyces lavendulae MB-733, a soil isolate; its spectral data were identical with those of moranoline from Morus species. Increased moranoline production was achieved through media improvement and mutagenic treatments (ultraviolet irradiation and N-methyl-N'-nitro-N'-nitrosoguanidine treatment): 27-33-fold augmentation (150 to 4000-5000 μg/ml) was obtained.

• 公益社団法人 日本農芸化学会の論文

著者

• MARUO Shigeaki

  Research Laboratories, Nippon Shinyaku Co., Ltd.

• MIYAZAKI Katsunori

  Research Laboratories, Nippon Shinyaku Co., Ltd.

関連論文

• Isolation of 2-Amino-2-deoxy-D-mannitol from Culture Broth of Streptomyces species(Microbiology & Fermentation Industry)
• Enzymatic Preparation of N-Substituted 4-(O-α-D-Glucopyranosylmoranoline Derivatives
• Moranoline (1-deoxynojirimycin) fermentation and its improvement.

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