Changes in Morphology of J774.1 Macrophage-like Cells and Release of Prostaglandin E2 Induced by Bacterial Acidic Polysaccharides

概要

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In an attempt to finding polysaccharides with immunostimulating activity, we isolated 14 bacteria that produced polysaccharides from soil. The polysaccharides produced by these bacteria and by strains kept in this laboratory and commercial polysaccharides were tested for ability to activate J774.1 macrophage-like mouse cells. Acidic polysaccharides, especially those from the newly isolated bacteria, induced spreading of the cells and release of prostaglandin E2 from the cells, which are manifestations of a state of activation. The prostaglandin E2-releasing activity of the polysaccharides was 1/10 to 1/20 on a weight basis of that of Escherichia coli lipopolysaccharide, a potent immunostimulant.
社団法人日本農芸化学会の論文