Solubilities and crystallization behavior of cimetidine polymorphic forms A and B.
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概要
- 論文の詳細を見る
For the polymorphic forms A and B of the organic compound cimetidine, their solubilities in H<SUB>2</SUB>O, 2-propanol (IPA) and H<SUB>2</SUB>O–IPA mixture and their crystallization behavior, mainly from IPA, were studied. It became apparent that form A is more soluble than form B in any solvent and that the solubilities of both forms increase in the order H<SUB>2</SUB>O, IPA, H<SUB>2</SUB>O–IPA mixture. In IPA as a solvent, at high supersaturation ratio (<I>S<SUB>A</SUB></I> ≥ 3.6), form A, which is of thermodynamically metastable form, was preferentially crystallized regardless of the presence or absence (<I>S<SUB>A</SUB></I> ≥ 4.5) and the form of seeds (<I>S<SUB>A</SUB></I> ≥ 3.6). Phase transition from form A to B was not observed. The primary nucleation rate of form A was also measured at <I>S<SUB>A</SUB></I> = 4.8–6.3 by the waiting-time method and surface energy <I>σ<SUB>A</SUB></I> was estimated to be 8.1 × 10<SUP>–3</SUP> J·m<SUP>–2</SUP>. At lower supersaturation ratio (<I>S<SUB>A</SUB></I> ≤ 2) the form corresponding to that of the seed was crystallized, contrary to results reported in earlier papers that no form B is obtained from IPA solution. The growth rate of form A was also measured at <I>S<SUB>A</SUB></I> = 2.2–1.3, by the light transmittance method, and <I>σ<SUB>A</SUB></I> was estimated to be 5.2 × 10<SUP>–3</SUP> J·m<SUP>–2</SUP>.
- The Society of Chemical Engineers, Japanの論文
著者
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Sato Katsutoshi
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Sudo Shogo
Department of Applied Chemistry, Faculty of Engineering, Osaka City University
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Harano Yoshio
Department of Applied Chemistry, Faculty of Engineering, Osaka City University
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