漁協関係女性における尿中ヒ素化合物パターンへの食事の影響評価
スポンサーリンク
概要
- 論文の詳細を見る
Background： Seafood and seaweed are part of the daily diet in Japan. Despite the essential nutrients theyprovide, concerns have been raised regarding the various forms of arsenic （As） in these foods. Becausepopulations living in coastal areas have better access to seafood and seaweed, it is important to study theirlevel of exposure to As from these dietary sources.Objectives： To examine the urinary As excretion profiles of and identify dietar y factors possiblyassociated with urinary As in Japanese women living in Choshi, a coastal area in Chiba prefecture.Methods： Daily nutrient intake was assessed by a diet history questionnaire （DHQ） and urinary Asspecies were determined by high performance liquid chromatography–inductively coupled plasma-massspectrophotometry（ HPLC-ICP-MS） in 92 participants, followed by statistical analyses of the data obtained.Results： The geometric mean （GM） of total urinary As was 248.3μg/g creatinine （μg/g cre）. Themain As metabolites in the urine were the organic compounds arsenobetaine（ AsBe）（ GM 163.4μg/gcre） and dimethylarsinic acid （DMA； GM 49.6μg/g cre）. The urinary inorganic As （iAs） concentrationwas low （GM 1.8μg/g cre）. Analysis on toxicologically relevant As species showed that the proportionof iAs, monomethylarsonic acid （MMA）, and DMA were 3.4％, 3.1％, and 91.6％（GM）, respectively,after removing AsBe and other As species from total As. Spearman's correlation coefficients showed thatseafood and seaweed intake was significantly correlated with％iAs （r=-0.34； r=-0.36, respectively）,％MMA （r=-0.25；r=-0.28, respectively）, and％DMA （r=0.33； r=0.37, respectively）. Intake of B vitamins,vitamin C, and soy isoflavones showed significant negative correlations with％iAs and％MMA, but positivecorrelations with％DMA.Conclusions：Japanese women from the coastal area of Choshi are exposed to low-level iAs. Their intakeof B vitamins and vitamin C was associated with proportions of urinary As species. We identified for thefirst time associations between estimated soy isoflavones intake and the proportion of urinary As species.
- 自治医科大学の論文
自治医科大学 | 論文
- 急性大動脈解離手術時に使用したGRF糊が原因と考えられる遠隔期基部大動脈仮性瘤の一例
- 止血用クリップを用いた腋窩動脈送血用側枝人工血管の閉鎖手技
- 胸部大動脈手術周術期における心房性不整脈の発生要因について
- シベレスタットナトリウム水和物による胸部大動脈緊急手術後集中治療期間の短縮効果
- 冠状動脈バイパス術中に大動脈近位側自動吻合器 : (PAS-Port proximal anastomosis system)不具合の1例