Prophylactic Antibiotic Administration for Prevention of Surgical Site Infection in Urological Laparoscopic Surgeries

概要

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Background: The purpose of this study is to investigate the occurrence of surgical site infection (SSI) in our cases after laparoscopic surgery with prophylactic antibiotics administration (PAA) of 1-2 days or 3 days duration. Methods: Two hundred and nine patients were enrolled in this study. SSIs were categorized as urinary tract and/or wound infection. Laboratory data relating to infection such as serum white blood cell (WBC) and C-reactive protein (CRP) were investigated after surgeries and compared to the data before surgeries. Data were collected and analyzed retrospectively. Results: There were 4 SSI patients in total. SSI was 4/125 (3.2 %) cases of PAA of 1-2 days (shorter) duration patients and there was 0/84 (0 %) of PAA of 3 days (longer) duration. Longer group showed the tendency of lower SSI ratio even though the difference did not reach statistically significant (p=0.0978) because of small number of SSI cases and ratios. Change of serum WBC at 4th day from pre-surgery was significantly suppressed in longer group than shorter group. Conclusions: Our data showed 3-days of PAA might be better to be selected according to the cases especially such as, for instance, immune-compromised hosts. Future prospective study with more number of patients may be necessary for further evaluation.
神戸大学医学部の論文