尿酸代謝における肝臓の生理的役割

概要

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The aim of the present study is to investigate the physiological role of the liver on uric acid metabolism in rats. We measured plasma uric acid levels in portal vein and hepatic vein in rats fed a standard diet or a high fat diet. The uric acid level of hepatic vain was lower than that of portal vain. This result showed that the liver was involved in uricolysis. In rats fed the high fat diet, the uric acid levels were elevated in both of portal and hepatic vains. The increase of visceral fats, which had caused by the high fat diets, would decrease a performance of uric acid metabolism in the liver. We also showed a significant positive correlation between serum uric acid level and abdominal circumference in human. In conclusion, our findings suggested that abstention from high fat diet and reduction of visceral fat are important for prevention of hyperuricemia.