Roles of epithelial-mesenchymal transition in squamous cell carcinoma of the temporal bone
スポンサーリンク
概要
- 論文の詳細を見る
Objectives: The authors recently demonstrated that extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone. The present objective was to investigate the expressions and the roles of epithelial-mesenchymal transition (EMT) in SCC of the temporal bone. Study Design: Retrospective patient file review and immunohistochemical study of tissues of patients with SCC of the temporal bone. Patients: The authors examined the expressions of vimentin in 16 patients with SCC of the temporal bone by immunohistochemical analysis. Results: As expected, vimentin was expressed on SCC of the temporal bone. We regard the patient who has vimentin-positive cells as EMT-positive patient because gain of vimentin is a hallmark in the EMT reported in several types of cancer. EMT positive tumors significantly correlated with extensive bone erosion, and extensive bone erosion correlated with a worse prognosis of the SCC of the temporal bone. Conclusion: The study results suggest that EMT in tumor cells becomes an important indicator of poor prognosis in SCC of the temporal bone. Copyright © 2011 Otology & Neurotology, Inc. Unauthorized reproduction of this article is prohibited.
論文 | ランダム
- ヨ-ロッパ社会の危機とマ-ストリヒト条約後のEC労働法 (リストラクチャリング時代の政策理念)
- T-User Code with Arbitrary Code Length for Multiple-Access Adder Channel (Special Section on Information Theory and Its Applications)
- Paleomagnetism of Miocene Sedimentary Rocks in the Kakegawa Area and Implication for Tectonic Rotation in Central Japan
- コムギのマイクロRNAの同定と検証
- 昆虫神経系の変態 (昆虫の神経制御)