線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 クロロキン剤の基礎と臨床（第一報）
スポンサーリンク
概要
- 論文の詳細を見る
Followings are the results derived from the treatment of animal and human cancers with a fibroblasts inhibiting agent such as chloroquine, based on the unique idea of ours. 1). In implanted tumors of animals, the effect was noted in Bashford cancer and Brown-Pearce cancer relatively rich in connective tissue in terms of life prolongation, an inhibition of tumor growth and of decrease of liver catalase activity, an improvement of iron metabolism, an enlargement of necrotic area in histology, an inhibition of connective tissue conponents, and a decrease of acid mucopolysaccharides. A tendency for a decrease of amount and cell numbers of ascites was almost the only effect noted in Ehrlich cancer, Yoshida sarcoma, and MH 134 poor in connective tissue. 2). 75 cases of humau cancer were treated with this agent and among these 75 the effect was evaluated in 40 cases with definite histological diagnosis in respects with subjective and objective improvement. It was effective in 28 cases, resulted failure in 11 cases, and gave an obscure result in 1 case. Cases which were treated for more than 2m onths never resulted in therapeutic failure, indicating that the agent was somehow effective for all cases but those in the last stadium. In respect with organs involved, the effect was most prominent in lung cancer and urinary bladder cancer, somewhat less in gastric cancer, and often seen in carcinomatous peritonitis and many other advanced cancers. This effect was noted in a comparatively short period in terms of subjective improvement, regression in size of tumors in a number of cases, a decrease of serum lactic acid dehydrogenase, and improvement of general condition, a tendency for necrosis of tumor and an inhibition of interstitium. 3). The above results indicate that the agent is more effective for tumors rich in connective tissue and that it's secondary effect on tumors through the inhibition of interstitial connective tissue is considered as the operative mechanism of chloroquine against malignant tumors, but it's anti-inflammatory effect and generalized influence on hosts are to be taken into consideration. The agent is indicated in inoperable cases, postoperative relapse, or prior and following an operation. A search for stronger fibroblasts inhibiting agents and an evaluation of combined therapy with so called anti-cancer agents are being made and that with mitomycin C is giving a fairly promising result.
- 岡山医学会の論文
- 1963-03-30
著者
関連論文
- F-72. ブレオマイシンによる肺癌の治療 : 治療 V
- 3)クロロキン(I-2 非特異的変調療法)
- 68.気管支喘息に対するキノリン誘導体の長期投与療法について(第11回日本アレルギー学会総会一般演題)
- レアギン型アレルギー反応における好塩基球の形態的変化 : アトピー型気管支喘息に関連して
- タバコ葉中の発癌性物質について : 中国・四国支部 : 第14回日本肺癌学会 中国・四国支部会
- 進行肺癌に対する化学療法 : 多剤併用療法およびIfosfamide大量療法の成績を中心に
- 早期肺癌に関する研究(第2報) : Bleomycinによる小型肺癌の治療
- 早期肺癌に関する研究(第1報) : 集団検診で発見された小型肺癌の診断について : 診断IV
- 肺癌のリンパ節転移の診断におけるリンパ系造影法の意義 : 造影診断
- 023. 農薬・有機フッ素剤中毒について
- 1718 農薬(有機塩素・有機弗素)中毒の経験例
- 農薬(有機塩素・有機弗素)中毒の経験例 : 要望課題8 最近における農薬の変遷と衛生学的諸問題 : 中毒(農薬)
- Leukemogenic Activity of Cell-free Filtrates of Radiation-induced Leukemia of RF Mice
- 333. 珪肺患者に対する燐酸クロロキン療法について : 附 珪肺患者に対するTHQ使用経験 (珪肺)
- 線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 クロロキン剤の基礎と臨床-1-
- 線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 クロロキン剤の基礎と臨床（第一報）
- 胃液中β-グルクロニダーゼ活性及びアインザイムによる胃癌, 殊に早期胃癌の診断