Leukemogenic Activity of Cell-free Filtrates of Radiation-induced Leukemia of RF Mice

概要

論文の詳細を見る
The incidence of leukemia in the RF mice exposed to a single whole body irradiation of 350 r X-rays was 77. 4%, 41 out of 53 mice. Of them, 20 animals developed the thymic type and 20 others the non-thymic type lymphocytic leukemia, while only one developed myelogenous leukemia. Comparative studies were made on the thymic and non-thymic type leukemia. By inoculating the cell-free filtrates from the leukemic RF mice induced by a single whole body X-irradiation to the newborn mice of the same strain younger than 16 hours old, two (16. 7%) of the twelve inoculated animals developed leukemia 375 and 374 days respectively after the inoculation. In the inoculation of the cell-free filtrates from normal mice to the newborn mice of the same strain, and in the non-irradiated control mice not a single case of leukemia developed. On the basis of these findings a discussion has been made on the role of virus in the induction of leukemia by X-ray irradiation.
日本放射線影響学会の論文