Long-Term Follow-Up of Autoimmune Pancreatitis: Characteristics of Chronic Disease and Recurrence
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概要
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Autoimmune pancreatitis is a unique disease, characterized by lymphoplasmacytic inflammation in the acute stages. However, the active clinical features are unlikely to persist for long periods. Through long-term follow-up, we investigated the disease course in 51 patients with autoimmune pancreatitis. We found recurrence in 21 (41%) patients and pancreatic stone formation in 9 (18%) patients. Pancreatic stone formation was significantly more frequent in the recurrence group (7/21, 33%), compared with the nonrecurrence group (2/30, 7%). Moreover, we found high serum immunoglobulin G4 concentrations in 13 of 175 (7.4%) patients with ordinary chronic pancreatitis. This suggested that pancreatic stone formation is closely associated with recurrence and that autoimmune pancreatitis might transform into ordinary chronic pancreatitis after several recurrences. We found that the immune complex level, with a cutoff value of 10 mu g/dL, served as a good predictor of recurrence, with high sensitivity (61.9%), specificity (70.0%), and efficacy (66.7%). We also confirmed that HLA and cytotoxic T-lymphocyte antigen-4 polymorphisms were useful predictors for AIP recurrence.
- ELSEVIER SCIENCE INCの論文
著者
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Kawa Shigeyuki
Department Of Surgery Suwa Red Cross Hospital
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Kawa Shigeyuki
Departments Of Second Department Of Internal Medicine Shinshu University School Of Medicine
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Kawa Shigeyuki
Second Department Of Medicine Shinshu University School Of Medicine
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Kodama Ryou
Department Of Gastroenterology Shinshu University School Of Medicine
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Takayama Mari
Department Of Gastroenterology Shinshu University School Of Medicine
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Ozaki Yayoi
Department Of Gastroenterology Shinshu University School Of Medicine
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Chou Yoshimi
Department Of Gastroenterology Shinshu University School Of Medicine
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Ochi Yasuhide
Department Of Gastroenterology Shinshu University School Of Medicine
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Arakura Norikazu
Department Of Gastroenterology Shinshu University School Of Medicine
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Kodama Ryo
Department Of Gastroenterology Shinshu University School Of Medicine
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Hamano Hideaki
Division Of Hepatology And Gastroenterology Department Of Medicine
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Ito Tetsuya
Department Of Gastroenterology Shinshu University School Of Medicine
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