急性頭蓋内圧亢進時の脳血管緊張に関する実験的研究―血圧上昇に対する頭蓋内圧の反応から―
スポンサーリンク
概要
- 論文の詳細を見る
This study was carried out to assess changes in cerebrovascular tonus in acute intracranial hypertension. Incremental increases of intracranial pressure (ICP) were induced in 42 dogs by intermittent inflation of a left fronto-temporal extradural balloon until the animals showed anisocoria, whereupon the balloon was deflated. ICP was continuously monitored using a pressure indicating-balloon in the bilateral extra- or intra-dural cavities. Blood pressure was abruptly increased by administration of angiotensin II at various levels of increased ICP (IICP). The cerebrovascular tonus was calculated as the ratio of the increase in mean ICP divided by the increase in mean blood pressure and was further defined as the local vasomotor capacitance index (LVCI). CO(2) reactivity of the cerebral vessels, an electroencephalogram (EEG) and the condition of the pupils were also observed. There was no significant difference between the bilateral hemispheres in local ICP (except at a balloon volume of 3 ml) and LVCI during IICP. The LVCI was 0.085±0.056 at normal ICP, and increased exponentially with increases in ICP. The maximum LVCI was 0.89. There were significant correlations between increases in the LVCI and decreases in cerebral perfusion pressure (CPP). The LVCI began to increase when CPP was below 80 mmHg, and increased markedly to more than 0.6 when CPP was below 40 mmHg. The CO(2) reactivity of cerebral vessels was completely impaired when transtentorial herniation developed. After deflation of the balloon, LVCI did not recover in 7 of 14 dogs. In these animals, CPP remained below 80 mmHg, and the EEG and pupils never became normal.
著者
関連論文
- 脳箆による脳圧迫の基礎的研究 : 特に術後に神経脱落症状を起こさないための術中の指標について
- 光電法による局所脳血液量測定の試み
- 24. 光電法による局所脳血液量測定
- 24. 光電法による局所脳組織内血液量測定(第52回日本医科器械学会大会)
- 49.頭蓋内Force Vector計測装置の試作(第51回 日本医科器械学会大会 講演集)
- 49. 頭蓋内Force Vector計測装置の試作 (第51回日本医科器械学会大会)
- 急性頭蓋内圧亢進時の脳血管緊張に関する実験的研究―血圧上昇に対する頭蓋内圧の反応から―