Blockade of interaction of α9 integrin with its ligands hinders the formation of granulation in cutaneous wound healing

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概要

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• The wound healing is a complex process consisting of inflammatory reaction, proliferation of mesenchymal cells, and formation and contraction of granulation tissue. The integrin receptors play crucial roles in this process. Recently, α9 integrin has also been detected on keratinocytes within wound sites. However, its functional significance at various wound healing processes was not fully elucidated. To address the role of α9 integrin in wound healing process, we made a full-thickness skin excisional wound and treated mice with anti-α9 integrin antibody. It has been shown that wound healing process was divided into three distinct phases; first, re-epithelialization phase, second phase of granulation tissue formation, and followed by final phase of contraction of granulation tissue. We found that contraction of granulation tissue was not impaired by blocking the interaction of α9 integrin with its ligands, indicating that α9 integrin is not involved in myofibroblast differentiation. Of note, formation of granulation tissue as characterized by dense vimentin and CD31 positive area was impaired. The hindrance of granulation tissue formation is due to the inhibition of adhesion and migration of α9 integrin positive dermal fibroblasts. In conclusion, α9 integrin is involved in the formation of granulation tissue via regulating migration and adhesion of dermal fibroblasts in the full-thickness skin excisional wound model.

• Nature Publishing Groupの論文

著者

• Matsui Yutaka

  Department Of Cardiovascular Medicine Graduate School Of Medicine Hokkaido University

• Uede Toshimitsu

  Division Of Molecular Immunology Institute For Genetic Medicine Hokkaido University

• Morimoto Junko

  Fukuoka University Hospital Kidney Center

• Kon Shigeyuki

  Divison Of Molecular Immunology Institute For Genetic Medicine Hokkaido University

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