Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction

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概要

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• Death associated protein 3 (DAP3) is crucial for promoting apoptosis induced by various stimulations. This report demonstrates that DAP3 is also important for T cell receptor (TCR)-mediated apoptosis induction in immature thymocytes. Enforced expression of DAP3 accelerated the negative selection in developing thymocytes, using the reaggregate thymus organ culture system. In addition, expression of DAP3 accelerated TCR-mediated apoptosis induction in DO11.10 cells. We also demonstrated that DAP3 translocates into the nucleus during TCR-mediated apoptosis in a Nur77 dependent manner. It is concluded that DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77.

• 2010-05-07

著者

• Miyazaki Tadaaki

  Divison Of Molecular Immunology Institute For Genetic Medicine Hokkaido University

• Tosa Noriko

  Division Of Molecular Immunology Institute For Genetic Medicine Hokkaido University

• Uede Toshimitsu

  Division Of Molecular Immunology Institute For Genetic Medicine Hokkaido University

• Murakami M

  Section Of Immunopathogenesis Institute Of Immunological Science Hokkaido University

• Machida Masaharu

  Department Of Molecular Immunology Institute For Genetic Medicine Hokkaido University Graduate Schoo

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