3′-Methyl-N-benzoyloxy-MABによる培養ラット肝細胞の癌化

スポンサーリンク

概要

• 論文の詳細を見る

• Cytotoxic effects, chromosomal aberrations and malignant transformation in a cloned rat liver cell strain(Ac2F) were examined by treatment with an active metabolite of 3'-methyl-4-dimethylaminoazobenzene(3'-Me-DAB), 3'-methyl-N-benzoyloxy-methylaminoazobenzene (3'-Me-N-benzoyloxy-MAB). The results are summarized as follows. 1) 3'-Me-N-benzoyloxy-MAB induced not only marked cytotoxic effects but also chromosomal aberrations on the cells when compared with 3'-Me-DAB. 2) The cells underwent malignant transformation at 51-53 days of culture after they had been treated three times with 6.9 ug/ml of 3'-Me-N-benzoyloxy-MAB. 3) 3'-Me-N-benzoyloxy-MAB-treated cells exhibited altered morphology, increased plating efficiency in liquid medium and increased size of aggregates in rotation culture, but not colony formation in semisolid agar medium or multinucleation by cytochalasin B. 4) These results strongly suggest that 3'-Me-N-benzoyloxy-MAB was an ultimate type carcinogen of 3'-Me-DAB.

• 岡山医学会の論文

著者

• 常盤 孝義

  岡山大学医学部附属癌源研究施設

関連論文

• N-acetoxy-methylaminoazobenzeneのクロ-ン化されたラット肝細胞株に対する影響
• 3′-Methyl-N-benzoyloxy-MABによる培養ラット肝細胞の癌化
• Effect of long-term administration of 4-(dimethylamino)azobenzene on liver cell line derived from rats fed this chemical(Note)
• 肝動脈塞栓術施行或は非施行ヒト肝癌組織の初代培養と株化
• N-acetoxy-methylaminoazobenzeneのクロ-ン化されたラット肝細胞株に対する影響
• 3′-Methyl-N-benzoyloxy-MABによる培養ラット肝細胞の癌化

スポンサーリンク