N-acetoxy-methylaminoazobenzeneのクロ-ン化されたラット肝細胞株に対する影響

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概要

• 論文の詳細を見る

• Cloned rat liver cells were treated with an ultimate carcinogen, N-acetoxy-methylaminoazobenzene(AcMAB) and 3'-methyl-4-dimethylaminoazobenzene(3'-Me-DAB) then various biological characters of the cells including tumorigenicity were examined. In regard to back-transplantation, after 11 days of experiments, a high concentration (5x10(-4)M) of AcMAB-treated cells formed tumors in one out of two rats. And a low concentration(1x10(-4)M) of AcMAB or 3'-Me-DAB-treated cells and untreated control cells did not form tumors. After 99 days of experiments, tumor formation was observed not only with the high concentration of AcMAB-or 3'-Me-DAB-treated cells but also with untreated control cells. AcMAB-treated cells had altered morphology and growth properties in vitro compared to 3'-Me-DAB-treated cells and untreated control cells. These results suggest an ultimate character of AcMAB, especially from the view point of tumor-forming capacity.

• 岡山医学会の論文

著者

• 常盤 孝義

  岡山大学医学部附属癌源研究施設

関連論文

• N-acetoxy-methylaminoazobenzeneのクロ-ン化されたラット肝細胞株に対する影響
• 3′-Methyl-N-benzoyloxy-MABによる培養ラット肝細胞の癌化
• Effect of long-term administration of 4-(dimethylamino)azobenzene on liver cell line derived from rats fed this chemical(Note)
• 肝動脈塞栓術施行或は非施行ヒト肝癌組織の初代培養と株化
• N-acetoxy-methylaminoazobenzeneのクロ-ン化されたラット肝細胞株に対する影響
• 3′-Methyl-N-benzoyloxy-MABによる培養ラット肝細胞の癌化

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