Prostaglandin F2α誘導体(ONO-995・CD)の神経因性膀胱に対する作用に関する実験的研究

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The effect of ONO-995. CD that was a derivative of prostaglandin F2a, on the neurogenic bladder was experimentally studied on rabbits with spinal cord injuries. Cystometrogram, EMG of the trigonal muscle of the urinary bladder, EMG of the bulbocavernosus muscle and electrical activity of the fourth sacral nerve or pelvic nerve were studied. The most predominant effects were obtained on the group of lower motor neuron lesion. Increased rhythmical contraction as well as contraction pressure and increased frequency as well as amplitude of EMG of the trigonal muscle were most predominant changes produced by ONO-995. CD. These results show that ONO-995. CD has a productive effect on voiding efficiency in neurogenic bladder. This effect was equally produced by oral use as well as intravenous use.
泌尿器科紀要刊行会の論文