[症例報告]術前化学寮法によって完全寛解になった進行食道癌の1例

概要

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The patient was a 59-year-old male who complained of dysphagia and thus was admitted to our hospital. He was diagnosed to have a type 3 advanced thoracic esophageal carcinoma lesion (Im-Ei) measuring 7cm in length based on both the X-ray and endoscopic findings. Intramural metastases were also observed. We thus diagnosed the patient to have advanced carcinoma with rapid vessel invasion and therefore chemotherapy was done first. He was treated by six cycles of combination chemotherapy, consisting of an intermittent infusion of cisplatin (1Omg/body/dayl-5/week) and a continuous infusion of 5-FU ( lOOOmg/body/24hour /day1-5/week). The chemotherapy regimen proved to be very effective. The tumor reduction rate was observed to be 68% on esophageal X-ray. After chemotherapy, no further carcinoma was found in a biopsy of the remaining mild rough mucosal membrane. The patient thus achieved a complete remission. Several areas of lymph node swelling of the left supraclavian region were observed, but we did not recognize any residual carcinoma. Nevertheless an operation was performed. A histopathological examination of the section revealed no carcinoma cells but only fibrotic changes in the proper muscular layer with no lymph node metastasis Two year and 2 months after operation, no signs of recurrence of carcinoma have been observed.
琉球医学会,Ryukyu Medical Associationの論文