[原著]Paget's Disease of the Breast : Report of Four Cases

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Paget's disease of the breast is one of the special types of breast cancers of rare incidence ; it is characterized by eczematous changes of the nipple and Paget's cell infiltration in the epidermis of the nipple. We encountered four cases of Paget's disease among the sixty cases of breast cancers we treated in the past five years. The incidence was 6.7 per cent, which is higher than that in other reported series. Two of the four cases had only nipple changes without breast tumors while the other two cases had both nipple changes and breast tumors. The mean age of the patients in the four cases of Paget's disease was 52.3 years while that of the patients with ordinary breast cancers was 53.2 years. The four cases were all treated by radical mastectomy. It was Velpeau^<8)> who first described the lesion of the nipple in 1840, which is known today as Paget's disease. Sir James Paget, an English surgeon, observed first the association of the erosion with a breast cancer in 1874. But Paget himself thought that the nipple change was a precancerous stage but not the cancer itself. In 1889, Darier^<1O)> first described the large cells with pale cytoplasms and prominent irregular nuclei which we now call Paget's cells ; but he regarded them merely as degenerated epidermal cells. It was Jacobaeus who, in 1904, first traced the origin of the Paget's cells from intraductal carcinoma in the nipple ducts. This has been supported by many investigators. Haagensen^<1)> states that .... it can be said that there is today general agreement that in all cases of Paget's carcinoma the disease is found not only in the nipple epidermis but also in the nipple ducts, and that in the great majority of cases there is also intraductal carcinoma of the mammary gland itself.
琉球大学保健学部の論文
1978-00-00

[原著]Paget's Disease of the Breast : Report of Four Cases

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琉球大学保健学部 | 論文

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