[原著］肺癌に対する Bleomycin + Adiamycin + ACNU(BAA) 療法

概要

論文の詳細を見る
We report in this paper, on the combination chemotherapy with BLM-ADM-ACNU (BAA) in treatment of lung cancer. Nine cases with lung cancer, which were judged to be inoperable because of the advanced disease were treated with our newly devised BAA combination chemotherapy. Histologicaly they were confirmed having small cell cancer in one case, and squamous cell cancer in eight cases. The administration of the drugs was as follows; 100 mg of ACNU was given through i. v. infusion once to twice every four weeks up to 300 to 400 mg, and BLM, 15 mg twice a week for the first two weeks and then the same dosis once every following week up to 200 mg and ADM, 20 mg twice a week for the first two weeks and then the same dosis two weeks later up to 200 mg. One case with small cell cancer responded strikingly to the treatment showing complete response. In the cases with squamous cell cancer, partial response in one case, minor response in another case were observed, and the other six cases showed no change. These ineffective cases were rather poor in their performance stata having some serious complications such as SIADH, DIC and drug-induced exanthema, and so on, which might have had adversely influenced upon the result of the treatment. As to the side effects of the treatment, alopecia was the most common manifestation and bone marrow suppression was observed in two cases. Regarding with ACNU, it was concluded that after the first administration of 100 mg of ACNU, about four-week interval is necessary for the second administration because of a delayed myelosuppressive reaction. None of the cases manifested cardiotoxicity bnd pulmonary fibrosis.
琉球大学医学部,Faculty of Medicine, University of the Ryukyusの論文

[原著］肺癌に対する Bleomycin + Adiamycin + ACNU(BAA) 療法

スポンサーリンク

概要

著者

関連論文

スポンサーリンク