Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia/reperfusion
スポンサーリンク
概要
- 論文の詳細を見る
We recently reported that excessive superoxide anion radical (O_2–•) was generated in the jugular vein during reperfusion in rats with forebrain ischemia-reperfusion using a novel electrochemical sensor and excessive O_2–• generation was associated with oxidative stress, early inflammation, and endothelial injury. However, the source of O_2–• was still unclear. Therefore, we used allopurinol, a potent inhibitor of xanthine oxidase (XO), to clarify the source of O_2–• generated in rats with forebrain ischemia-reperfusion. The increased O_2–• current and the quantified partial value of electricity (Q), which was calculated by the integration of the current, were significantly attenuated after reperfusion by pretreatment with allopurinol. Malondialdehyde (MDA) in the brain and plasma, High-mobility group box 1 (HMGB1) in plasma, and intercellular adhesion molecule-1 (ICAM-1) in the brain and plasma were significantly attenuated in rats pretreated with allopurinol with dose-dependency in comparison to those in control rats. There were significant correlations between total Q and MDA, HMGB, or ICAM-1 in the brain and plasma. Allopurinol pretreatment suppressed O_2–• generation in the brain-perfused blood in the jugular vein, and oxidative stress, early inflammation, and endothelial injury in the acute phase of forebrain ischemia-reperfusion. Thus, XO is one of the major sources of O_2–• in blood after reperfusion in rats with forebrain ischemia-reperfusion.
- 2009-12-11
著者
-
Kutsuna Satoshi
Advanced Medical Emergency And Critical Care Center Yamaguchi University Hospital
-
FUJITA MOTOKI
Advanced Medical Emergency And Critical Care Center, Yamaguchi University Hospital
-
MAEKAWA TSUYOSHI
Advanced Medical Emergency And Critical Care Center, Yamaguchi University Hospital
-
Maekawa Tsuyoshi
Advanced Medical Emergency And Critical Care Center Yamaguchi University Hospital
-
Maekawa Tsuyoshi
Department Of Critical Care And Emergency Medicine School Of Medicine Yamaguchi University
-
Fujita Motoki
Advanced Medical Emergency And Critical Care Center Yamaguchi University Hospital
-
Tsuruta Ryosuke
Advanced Medical Emergency And Critical Care Center Yamaguchi University Hospital
-
Ono Takeru
Advanced Medical Emergency And Critical Care Center Yamaguchi University Hospital
関連論文
- Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia/reperfusion
- Mixed Connective Tissue Disease with Multiple Organ Damage: Successful Treatment with Plasmapheresis
- Associations between markers of inflammation and cholinergic blockade and delirium in intensive care unit patients: A pilot study
- Effect of Intravenous Magnesium Sulfate on Cardiac Arrhythmias in Critically Ill Patients with Low Serum Ionized Magnesium
- Synchronized Changes in Serum Vascular Endothelial Growth Factor during the Clinical Course of Chronic Systemic Capillary Leak Syndrome
- Methanol Intoxication : Differential Diagnosis from Anion Gap-increased Acidosis
- Fatal Skullbase- penetrating Brain Injury with Pruning Shears: Case Report
- Successful treatment with hydrocortisone for heat stroke with critical illness-related corticosteroid insufficiency : transitional changes in serum cytokine and cortisol concentrations
- Cerebral Circulation and Prognosis of the Patients with Hypoxic Encephalopathy
- Evaluation of Body Motion by Optical Flow Analysis
- Contactless Measurement of Carrier Lifetime in Silicon Thick Wafers
- Effect of Enteral Nutrition on Intestinal Permeability in Critically III Patients -Preliminary Report-
- Diastolic Plateau Wave of Pulmonary Artery Pressure in Severe Congestive Heart Failure
- Generation of Lamb Wave Using Linear Array Probe and Its Application for Flaw Detection : Ultrasonic Microscopy and Nondestructive Testing
- Two-Dimensional Ultrasonic Scanning Method Using a Circular-Array Transducer : Ultrasonic Transduction
- Detection of Physiological Parameters without Any Physical Constraints in Bed Using Sequential Image Processing
- Complete recovery from severe myocardial dysfunction in a patient with anorexia nervosa
- Corticosteroid Therapy for Hemolytic Anemia and Respiratory Failure Due to Mycoplasma pneumoniae Pneumonia
- Evaluation of peripheral circulation in critically III patients by pulsed doppler ultrasonography
- Candida dubliniensis Isolated from the Sputum of a Patient with End-stage Liver Cirrhosis