温度とpHに応答する相互貫入型ヒドロゲル膜の作製

概要

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The novel thermo-and pH-responsive interpenetrating polymer network hydrogel films (IPN: r-IPN and b-IPN) as biomedical materials were prepared from the polymerization of N-isopropylacrylamide [NiPAAm] in the presence of methylenebisacrylamide as a cross-linker and random or block copolymers composed of thermo-responsive poly(N-isopropylacrylamide)[PNiPAAm] segments and pH-responsive poly(O-meth-acrylyl-L-serine)[poly(SerMA)] segment. The random copolymer was prepared from the copolymerization of NiPAAm and SerMA precursor initiated with 2,2'-dimethylazobisisobutyrate (MAIB) as an initiator. The block copolymer was prepared from the radical polymerization of SerMA precursor initiated with the PNiPAAm azo-initiator. Two kinds of hydrogel ，r-IPN and b-IPN hydrogel，exhibited the reversible volume phase transition，swelling ⇔ shrinking，behavior in response to external stimuli such as temperature and pH.