感温性ポリ[N-(2-ヒドロキシプロピル)メタクリルアミド-ジメチルシロキサン]ブロックコポリマーのキャラクタリゼーション

概要

論文の詳細を見る
Block copolymers, Poly (HPMA b-DMS)-1〜7, were obtained from polymerization of N-(2-hydroxypropyl) methacrylamide (HPMA) initiated with polydimethylsiloxane (PDMS) type of azo-initiator [4, 4'-azobis (polydimethylsiloxane)-4-cyanopentanoate (azo-PDMS)]. From XPS measurements of freeze dried samples, the hydrophilic PHPMA segment was found to migrate to the surface of Poly (HPMA-b-DMS) films in water. Poly (HPMA-b-DMS) showed lower contact angle (θ=54°〜100°) than PDMS itself (θ=103°). It was also found that the contact angle of block copolymers was changed in response to change in temperature, i.e., θ=64°〜79° at 40℃ and θ=54°〜69°at 20°for Poly (HPMA-b-DMS). The amount of adsorption of albumin on the Poly (HPMA-b-DMS) film was depressed at 20℃ compared to the case at 40℃. For the purpose of an application to a thermo-responsive drug delivery system, copolymer hydrogel Gel (HPMA b-DMS) was also prepared by radical copolymerization of HPMA and N, N'-ethylenebisacrylamide initiated with azo-PDMS.
2006-04-15