サンセファール(cefpiramide) の前立腺および膀胱壁移行に関する検討

概要

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前立腺および膀胱の切除術を行った21例を対象として,cefpiramide (CPM) 2 gを静注し,一定時間後の前立腺および膀胱壁組織への移行性を検討し,薬動力学的解析を行った.1)前立腺組織移行は投与後12分～3時間40分で28.4～131 μg/g,対血清比は0.15～0.63であった.また前立腺組織内のGPM半減期は3.29 hrを示した.膀胱壁については症例が2例と少ないが,いずれも高濃度を示した.2) CPMの前立腺および膀胱壁組織への移行は良好であり,その強い抗菌力と相まって,術後感染症の治療に有用性の高い薬剤であるThe cefpiramide (CPM) concentration in prostatic tissue of 19 patients with benign prostatic hypertrophy and bladder wall of 2 patients with bladder tumors was measured, after 2 g of CPM was administered intravenously by bolus technique prior to operation. Prostatic tissue level was 28.4 to 131 micrograms/g and tissue to serum ratio 0.15 to 0.63 at 12 min. to 220 min. after administration. The T1/2 of CPM in prostatic tissue was 3.29 hours. The bladder wall level was high at both determinations. CPM level in prostatic tissue and bladder wall covered the minimum inhibitory concentration of many bacteria detected from the infected sites. Therefore, CPM which has a strong antimicrobial activity can be considered as a highly useful antibiotic for the treatment of postoperative infections.