精巣腫瘍におけるTopo 1阻害剤のプラチナ化合物の効果増強について

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ヌードマウス可移植ヒト精巣腫瘍株を用い,CPT-11とCDDPなどのプラチナ化合物との併用療法により,抗腫瘍効果の著しい増強がみられることを示した。この結果をふまえ,4例の難治性精巣腫瘍に対しCPT-11とCDDPや254-Sによる併用療法を行い,2例でその有効性が示されたThe antitumor effects of combination chemotherapies using CDDP and the camptothecin analogue CPT-11 were compared with those of vinca alkaloids or podophyllotoxins, and those of CPT-11 and cisplatinum analogues were also estimated. Two human testicular cancer xenografts (TTSC -2 and TTSC-3) heterotransplanted in nude mice were used. Combination therapy with CPT-11 and CDDP resulted in significant tumor regression and was much more effective than that of CDDP and vinca alkaloids or podophyllotoxin. The combination of CPT-11 and either CDDP or 254-S was significantly more effective than that of CPT-11 and either carboplatin or DWA2114R. Four evaluable refractory testicular cancers were treated with combination chemotherapy with CPT-11 and CDDP or 254-S as third line chemotherapy. Two patients remain alive and disease free and two patients died of disease. We concluded that the present combination is active in refractory testicular cancer.

著者

古武敏彦
腎癌免疫療法研究会

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