インポテンス(IMP)患者に対する心電図R-R間隔変動係数(CV)の測定

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IMP患者についてその原因を検索するためのスクリーニングテストとして心電図R-R間隔CVを測定し,副交感神経障害に起因するものか否かについて検討した.CV 2.0以下のlow CVを呈し,副交感神経障害によるIMPと考えられた症例は,IMP患者762例中104例であった.このうちの50例に明らかな副交感神経障害因子が見出され,12例に副交感神経障害を起こす可能性のある因子が見出された.障害因子を見出すことができなかったものは42例であったThe coefficient of variation (CV = SD/mean x 100) of the R-R interval in electrocardiogram (ECG) was measured as an indication of parasympathetic nerve function in patients with impotence. Of 762 patients 104 (13.6%) had a CV value lower than 2.0. The factors which led to the low CV value were evident in 50 patients (48%), i.e. diabetes mellitus in 26, side effects by antiulcer, antidepressant or antihypertensive agent in 16, renal failure in 1, alcoholism in 2 and age over 70 years old in 4. The possible factors of the low CV value, such as neurogenic, thyroid, cardiovascular and endocrine disorders were found in 12 patients (11.5%). In the remaining 42 patients (40.4%), CV value was decreased by unknown factors. Measurement of CV of R-R interval in ECG was safe and useful as a screening test for patients with impotence to detect the dysfunction of the parasympathetic nerve system.