根治的膀胱全摘除術を施行した膀胱癌症例の臨床的検討

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1979年からの15年間に滋賀医科大学泌尿器科において膀胱全摘除術を行った105例の膀胱移行上皮癌症例を臨床的に検討した. 1)全例の5年生存率は68.9%であった. 2)異型度ではG2,G3例間の生存率に有意差を認めた. 3)深速度ではpT3例がpTa例に,pT4例がpTa, pT1, pT2例に比べ,それぞれ有意に不良な転帰を示した. 4)pN(+)例はpN0例に比べ有意に不良な転帰を示したWe assessed the treatment outcome of 105 patients with transitional cell carcinoma of the bladder treated by total cystectomy at our university hospital, between 1979 and 1993. The patients consisted of 84 men and 21 women (male to female ratio : 4:1), between 45 and 82 years old (mean, 65.5 years old). The overall cancer-specific survival rate at 3 and 5 years was 76.3% and 68.9%, respectively. The 5-year survival rate was 85.2% for grade 2 and 59.9% for grade 3 tumors with a significant difference in the survival curves between the two groups (p < 0.05). The 5-year survival rate according to pathological stage was 100% for pTa, 75.6% for pT1, 78.4% for pT2, 54.0% for pT3 and 39.8% for pT4. A significant difference was observed between pTa and pT3 (p < 0.05), and between pTa-2 and pT4 (p < 0.05). The 5-year survival rate was 72.3% for patients without lymph node involvement and 11.9% for those with lymph node involvement, the difference being significant (p < 0.01). Nineteen patients who received pre- and/or post-operative chemotherapy did not show a higher 5-year survival rate than those who did not.

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浜口晃一
滋賀医科大学泌尿器科

根治的膀胱全摘除術を施行した膀胱癌症例の臨床的検討

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