Ureaplasma urealyticumによる実験的膀胱結石

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1)U.urealyticumの感染性は弱く,尿培養で,菌接種後2日目に既に36匹中10匹は陰性であり,更に2日目に陽性ラットも,その後の尿培養で,時間の経過と共に菌は尿中より陰性化する傾向があった. 2)U.urealyticum感染により,ごく軽度の尿pHの上昇がみられるのみであった. 3)術後2日目の尿中にU.urealyticumがみられたラットでは,69%に膀胱内に結石が形成され,又,術後6日目も尿中にU.urealyticumが陽性であったラットでは71%に結石がみられたWe examined the relationship between struvite stone formation and Ureaplasma urealyticum in male Wister rats by inoculating U. urealyticum and implanting a zinc disc into the bladder surgically. Cultures of U. urealyticum and pH measurements in urine obtained by forced urination were done on days 2 and 6 after operation. Half of the rats were killed 7 days after the operation and the remaining half 14 days after the operation. A total of 46 rats, consisting of 10 rats in the control group and 36 rats inoculated with U. urealyticum, were studied. U. urealyticum was weakly virulent, because it was not detected in the urine culture on day 2 in 10 of the 36 rats inoculated with the organism, and showed a tendency towards spontaneous elimination in the other rats. Urinary pH was elevated slightly by the presence of U. urealyticum. Struvite stones were formed in 52% of the rats by the inoculation on of U. urealyticum, and 69% and 71% of the positive rats in urine culture for U. urealyticum on day 2 and day 6 respectively. The stones tended to be larger the longer U. urealyticum was detected in urine. U. urealyticum may play a role in struvite stone formation, but not a major role.

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竹内秀雄
神戸市立中央市民病院泌尿器科

Ureaplasma urealyticumによる実験的膀胱結石

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