低比重リポ蛋白受容体欠損による高脂血症マウス腎における単球遊走因子(MCP-1)の発現

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Abnormalities in lipid metabolism appear to play a pivotal role in progressive renal diseases.Monocyte chemoattractant protein (MCP)-1 plays pivotal roles in several inflammatory conditions including renal damage in diabetes.However,the pathogenesis of MCP-1in renal injury induced by hypercholesterolemia remains unclear. To clarify the pathophysiology of hypercholesterolemia in renal diseases, we performed immunohistochemistry and reverse transcription-polymerase chain reaction to detect MCP-1and the adhesion molecules vascular cell adhesion molecule (VCAM)-1and intercellular adhesion molecule (ICAM)-1in kidneys from low density lipoprotein receptor knockout (LDLRKO)mice fed lipid-rich chow (n＝12).They were harvested at 5 to 10weeks. For the control study, kidneys from wild mice fed lipid-rich chow and LDLRKO mice fed normal chow were also harvested.Severely high levels of hypercholesterolemia were seen in the serum of the LDLRKO mice,while no serum cholesterol elevation was observed in the wild mice.MCP-1 was enhanced in the glomerular endothelial cells and proximal tubular cells in the kidneys of LDLRKO mice, and this enhancement appeared prior to the expression of adhesion molecules and interstitial cell infiltration. Conversely,this expression was not enhanced in the control mice.We conclude that MCP-1expression in renal glomerular and tubular cells may play important roles in renal diseases induced by hypercholesterolemia, and that the expression can be a useful marker for the early diagnosis of renal injury.
信州医学会の論文
1999-10-10

低比重リポ蛋白受容体欠損による高脂血症マウス腎における単球遊走因子(MCP-1)の発現

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