Hormone levels in the saliva of lactating Vietnamese mothers in a dioxin hot-spot area

概要

論文の詳細を見る
【目的】アメリカ軍は１９６１年から１９７１年の間に８０００万リットル以上の枯葉剤を南ベトナムに撒布した。この研究の目的はベトナムの枯葉剤高濃度汚染地域（Binh Dinh省Phu Cat県）と非汚染地域（Ha Nam省Kim Bang県）において枯葉剤（オレンジ剤）の暴露と人体への健康影響との関連を検討することである。【方法】２つの地域において疫学的調査を実施した。対象者は授乳中で生後４週から１６週の乳児を持つ２０－３０歳の母親とし、汚染地域では５８名、非汚染地域では５３名であった。疾患の危険因子等に関する情報は母親への面接調査から得た。母乳をすべての対象者から採取したが、唾液を採取したのは汚染地域４１名、非汚染地域１９名であった。母親と子どもの身体計測を行い２地域間で比較を行った。【結果と考察】汚染地域における乳児の体重と胸囲は有意に非汚染地域よりも小さいが、年齢(週数)も汚染地域の方が有意に低かった。汚染地域における母親とその家族の現病歴は非汚染地域よりも有意に多かった。母親の視力は両眼とも２地域間で有意差は認められなかった。汚染地域と非汚染地域双方の母親の唾液中のコルチゾン値は、母乳中のコルチゾン値と高い相関を示した。汚染地域と非汚染地域間で唾液中のホルモン値には有意差は認められなかった。Objective : Between 1961 and 1971 the US military used over 80 million litres of herbicides in southern Vietnam. This study aims to assess hormone levels in thesaliva of lactating Vietnamese mothers and human health effects in a dioxin hot spot (Phu Cat district, Binh Dinh province) and a non-exposed (Kim Bang district,Ha Nam province) area in Vietnam. Materials and Methods : An epidemiological study was carried out in both areas. The subjects were 58 lactating females in thehot spot area and 53 lactating females in the non-exposed area. All were aged between 20 and 30 years with infants aged between 4 and 16 weeks. Informationabout disease risk factors was obtained through interviews with mothers. Breastmilk samples were taken from all subjects, whereas saliva samples were obtainedfrom 41 mothers in the hot spot area and 19 in the non-exposed area. Body measurements for both mothers and their infants were compared between the twoareas. Result and Discussion : The weight and chest circumference of infants in the hot spot area were significantly lower than those in the non-exposed area, whereas age (weeks) is also significantly younger in hot spot area than non-exposed area. Present maternal and family diseases in the hot spot area were significantly higher than those in the non-exposed area. Maternal eyesight in both eyes did not differ significantly between the two areas. The cortisone levels in saliva have been found to be closely related to those in breast milk samples of both mothers in hot spot and non-exposed areas. No significant difference was found between salivaryhormone levels of mothers in the hot spot and non-exposed areas.
2009-12-25

Hormone levels in the saliva of lactating Vietnamese mothers in a dioxin hot-spot area

スポンサーリンク

概要

著者

関連論文

スポンサーリンク